Engineering the cellular fluidic microenvironment
Our group works hard to make progress in both technology development and molecular cell biology, and our training objective is that each trainee develops an in-depth understanding of engineering principals and cell biology by the time they leave the lab. Broadly, our work is organized around 3 distinct but overlapping research thrusts:
Technology
3D Microfluidics
Perfusable blood and lymphatic vascular models to understand fluid-structure interactions in the microvasculature.
Mechanism
Endothelial cell adhesion
Understanding Notch family receptor signaling in mediating fluid stress sensing and cell-cell junction dynamics.
Translation
Cardiovascular disease
Humanized disease models of rare, inherited vascular disease for drug screening and target identification.